Interpretation Guidelines

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Interpretive Guidelines

Interpretive Guidelines helps patient and practitioner to understand what to do when hormone levels are imbalanced.

Hormone Result Possible Causes Treatment Consideration
Estrone (E1) Low Ovarian dysfunction Support co-factors for steroid production and ovarian function
Adrenal insufficiency Assess and support adrenal hormones
High Excessive aromatization Assess and support liver detoxification
Impaired Phase II liver detoxification Assess 2+16 hydroxylation pathways
Exogenous supplementation stress or inflammation Dietary evaluation for weight loss if increased BMI is noted.
Assess and support adrenal health
Reduce exposure to xenoestrogens
Indole 3-carbinol/DIM/cruciferous vegetables to assist with metabolism and detoxification of steroids
Estradiol (E2) Low Reduced ovarian function Support co-factors for steroid production, including boron (which interacts with steroid hormones by facilitating hydroxylation reactions, and possibly acts to protect steroid hormones from rapid degradation)
Adrenal insufficiency Assess and support adrenal hormones
Elevated SHBG (which leads to low bio-available E2) Assess and support bone mineral loss
High Ovarian dysfunction Assess and support liver detoxification
Adrenal insufficiency Assess 2+16 hydroxylation pathways
Excessive aromatization Dietary evaluation for weight loss if increased BMI is noted (fewer fat cells = less aromatase to convert TT to E2 and androstenedione to E1)
Impaired Phase II liver Reduce exposure to xenoestrogens
detoxification Indole 3-carbinol/DIM/cruciferous vegetables to assist with metabolism and detoxification of steroids
Exogenous supplementation Assess thyroid hormone levels (high E2 may interfere with tissue action of T3)
Low SHBG
Estriol (E3) Low Ovarian dysfunction Support co-factors for steroid production and ovarian function
Adrenal dysfunction Assess and support adrenal hormones
High Increased conversion from E1 Assess and support 2+16 hydroxylation pathways
Exogenous supplementation
Testosterone (TT) Low FEMALE FEMALE
Adrenal dysfunction Assess and support adrenal hormones
Ovarian dysfunction Assess and support ovarian function
Acetyl-L-Carnitine may increase TT (by influencing acetylcholine
neurotransmission in the striatal cortex of brain)
Zinc (cofactor for support of TT)
MALE MALE
Testicular insufficiency Assess and manage adrenal dysfunction
Adrenal dysfunction Herbal support such as Siberian ginseng, damiana, licorice
High FEMALE FEMALE
Ovarian and/or adrenal Assess and support liver detoxification
dysfunction Dietary evaluation for weight loss if increased BMI is noted
Excessive aromatization Assess and support ovarian function
impaired Phase II liver Assess and support adrenal hormones
detoxification (check sulphation and glucuronidation pathways) Assess blood sugar regulation
Increase SHBG if low (dietary fiber, flaxseed, soy, weight loss)
Assess thyroid function
Exogenous supplementation Manage any underlying insulin resistance. Insulin lowers SHBG, therefore increasing free TT.
Low SHBG Manage any underlying progesterone deficiency
Increased stress Aromatase Inhibitors (which stop conversion to E2 – natural aromatase inhibitors include exercise, chrysin, isoflavones)
Insulin resistance
Low thyroid function
PCOS
MALE MALE
Testicular dysfunction Indole 3-carbinol/DIM/cruciferous vegetables to assist with metabolism and detoxification of steroids
Adrenal dysfunction Assess and manage adrenal dysfunction
Low SHBG Increase SHBG if low (dietary fibre, flaxseed, soy, weight loss)
Assess thyroid function
Manage any underlying insulin resistance
Herbal support such as Serenoa repens, Vitex agnus-castus
DHEA-S/DHEA Low Low Adrenal dysfunction Consider lifestyle, dietary and herbal options outlined under high cortisol if warranted (to correct the balance of these hormones)
Androgen dysfunction DHEA-S or pregnenolone supplementation may be warranted
Consider measuring testosterone and/or estradiol levels and manage accordingly
High Adrenal dysfunction Consider lifestyle, dietary, and herbal options outlined under low cortisol if warranted (to correct the balance of these hormones)
Androgen dysfunction Weight loss
Assess testosterone and/or estradiol levels and manage accordingly
Progesterone (P4) Low Adrenal dysfunction Assess and support adrenal and steroid hormones
Excess estrogens Support liver detoxification
Thyroid insufficiency Herbal support such as Vitex agnus-castus
Progesterone therapy
Optimize thyroid function (low P4 may be symptomatic of low T3 as ovaries need T3 to secrete adequate P4)
High Excess progesterone Re-evaluate progesterone dosage as required (prolonged excessive progesterone supplementation may lead to down regulation of P4 and E2 receptors and possible deficiency symptoms even if levels are elevated)
supplementation Indole 3-carbinol/DIM/cruciferous vegetables to assist with metabolism and detoxification of steroids
Adrenal dysfunction Support liver detoxification
Cortisol Low Adrenal dysfunction Low doses of adrenal hormone usually quickly banishes the symptoms of low blood sugar
Adrenocorticotropic hormone (ACTH) deficiency
Low Blood Pressure
High Cushing’s Syndrome Measurement of morning and late night
Increased Stress Vitamin C 500-1000 mg/day
Adrenal Fatigue Pantothenic acid, a B vitamin, also supports adrenal function
Sugar Craving  Cutting sugar and Caffeine, increase intake of proteins, decrease carbohydrates.
Weight Gain Disabling Chronic fatigue should be given a low- dose trail of adrenal hormone.
High Blood Pressure
Allergies
Sleeping disturbances

Estrogen Dominance

Balance of progesterone and estrogen is important .

Progesterone: Estradiol Ratio (P4:E2)                                             

The levels of both progesterone and estradiol are important and equally so is the delicate ratio between them. The ratio must be in the range of 200-300:1 (P4:E2), meaning for every 200-300 units of progesterone there must be 1 unit of estradiol.